COLLAGEN FIBRILS CARRYING BIOACTIVE HETEROLOGOUS DOMAINS AND THEIR USE IN E.G. WOUND HEALING

摘要

A modified pro-alpha chain comprising a triple helix forming domain linked to at least an N-terminal domain, the N-terminal domain containing a polypeptide from at least part of a laminin glycoprotein or secretory leukocyte protease inhibitor. The pro-alpha chain may form part of a procollagen molecule that has the N-terminal domain retained. The procollagen molecules may be incorporated into collagen polymers, matrices and gels and be used for such applications as wound healing.