OPTICAL FIBER ARRAY BIOCHIP BASED ON WHITE-LIGHT REFLECTROMETRIC INTERFERENCE SPECTROSCOPY

摘要

The invention discloses an optical fiber array biochip based on white-light reflectrometric interference spectroscopy to detect the presence and the change of a certain biological (or chemical) substance. In the biochip, the optical fiber is used to be the biosensor. A layer or several layers of material different from the optical fiber and the analyte to be detected are coated on the end of the optical fiber, which is the sensing reference for a membrane reflectrometric interferometer. Among these, at least a layer is the complementary material that could attach the target biological (chemical) molecular. After the molecular to be detected is attach to the surface of the complementary material or therein, the spectrum of the reflective interference light would be changed. The spectral-line shift could be used to quantitatively or qualitative analyze concentration, absorbing rate, and dimensional change of sample molecular. A plurality of optical fibers could be arranged into linear array or planar array. In this manner, equipped with N:1 optical fiber couplers, one reagent with many indices or many reagents with many indices could be simoultaneously assayed with one detector.