AN ASSAY FOR DETECTING THE PRESENCE OF PROCESSING INHIBITORY ANTIBODIES AGAINST THE APICAL MEMBRANE ANTIGENE-1 OF PLASMODIUM FALCIPARUM IN BIOLOGICAL SAMPLES

摘要

In this application is described a method for determining the presence or absence of functional anti-AMA-1 invasion-inhibitory antibodies in a sample. This method can serve as a correlate for immunity of a P. falciparum AMA-1-based vaccine or as a correlate for immunity to P. falciparum by natural exposure if that immunity was induced by invasion inhibitory antibodies against the AMA-1 protein.