Use of an Equine herpes virus type-4 thymidine kinase and a nucleoside analog selected from ganciclovir and acyclovir for the killing of human proliferative cells

摘要

Use of an equine herpes virus type 4 (EHV4) thymidine kinase (TK) polypeptide (I), or a nucleic acid (II) encoding (I), to produce a composition for rendering human cells sensitive to a nucleoside analog (III), in vitro, ex vivoor in vivo, is new. An independent claim is also included for a pharmaceutical composition for treating human cell proliferative diseases containing (I) or (II), and optionally also (III). ACTIVITY : Antitumor; antiproliferative. No biological data is given. MECHANISM OF ACTION : Nucleoside analog phosphatase.