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use of equiner herpes virus type 4 - thymidine kinase and a nucleosidanalog selected by ganciclovir and acyclovir to kill proliferative human cells
use of equiner herpes virus type 4 - thymidine kinase and a nucleosidanalog selected by ganciclovir and acyclovir to kill proliferative human cells
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机译:使用马匹疱疹病毒4-胸腺嘧啶核苷激酶和更昔洛韦和阿昔洛韦选择的核苷类似物杀死增殖性人类细胞
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摘要
Use of an equine herpes virus type 4 (EHV4) thymidine kinase (TK) polypeptide (I), or a nucleic acid (II) encoding (I), to produce a composition for rendering human cells sensitive to a nucleoside analog (III), in vitro, ex vivoor in vivo, is new. An independent claim is also included for a pharmaceutical composition for treating human cell proliferative diseases containing (I) or (II), and optionally also (III). ACTIVITY : Antitumor; antiproliferative. No biological data is given. MECHANISM OF ACTION : Nucleoside analog phosphatase.
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