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COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY
COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY
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机译:增强认知功能和突触可塑性的组合物和方法
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摘要
The present invention provides compositions and methods for enhancing cognitive function and synaptic plasticity. According to the method, Ca++ influx into excitatory neurons (nerve cells) is decreased by treatment with a number of different agents including divalent cations (e.g., Mg++), GABAB agonists, GABAA agonists, calcium channel blockers, and/or compounds that decrease action potential firing such as sodium channel blockers. Decreasing Ca++ influx results in increased synaptic plasticity and enhanced cognitive function. In particular, decreasing Ca++ influx associated with uncorrelated neural activity results in long-lasting increases in synaptic plasticity and cognitive function. This is achieved by administration of agents that cause a voltage-dependent block of NMDA receptors (e.g., divalent cations such as Mg++) or by administration of GABAB agonists such as baclofen. The invention further provides screening methods useful in identifying compounds that enhance synaptic plasticity and cognitive function.
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机译:本发明提供了增强认知功能和突触可塑性的组合物和方法。根据该方法,通过用许多不同的试剂进行治疗,包括进入二价阳离子(例如,Mg ++),GABAB激动剂,GABAA激动剂,钙通道阻滞剂和/或降低作用的化合物,可减少Ca ++进入兴奋性神经元(神经细胞)的流入潜在的射击,例如钠通道阻滞剂。 Ca ++内流减少导致突触可塑性增加,认知功能增强。特别是,减少与不相关的神经活动相关的Ca ++流入量会导致突触可塑性和认知功能的持久增加。这可以通过施用引起电压依赖性NMDA受体阻断的试剂(例如二价阳离子,例如Mg ++)或通过施用GABAB激动剂,例如巴氯芬来实现。本发明进一步提供了可用于鉴定增强突触可塑性和认知功能的化合物的筛选方法。
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