MODULATORS OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE AND METHODS OF USE THEREOF

摘要

The present invention provides methods of identifying agents that increase dimethylarginine dimethylaminohydrolase (DDAH) levels and/or activity. The present invention further provides agents that increase DDAH levels and/or activity, and compositions comprising the agents. The invention further provides methods of treating insulin resistance, and methods of lowering blood glucose levels in an insulin-resistance individual, the methods generally involving administering to the individual an agent that increases DDAH levels and/or activity. The invention further provides methods of treating conditions in which plasma or tissue ADMA levels are elevated, by increasing the activity or expression of DDAH.