CELL LINE COMPRISING THE PROMOTER OF CYCLOOXYGENASE-2 (COX-2) AND A WITNESS GENE, AND USE THEREOF IN THE SEARCH OF COX-2 TRANSCRIPTIONAL INDUCTION SELECTIVE INHIBITORS

摘要

Cell line includes the structure of a DNA, sequence (cyclooxygenase-2 COX-2) gene including an all or part of promoter witnesses gene, it is operatively connected to one another, so that the gene said witness of the expression of the sequence guidance COX-2 genes of the promoter is in response to adequate stimulus. The measuring method includes making the cell line and compound to be analyzed and determining there are a signal, indicates the activity of expression since the inhibitor that Said witnesses the induced selective that genetic method is adapted to search for COX-2 transcriptions passes through stimulation appropriate.