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PROCESSES FOR PREPARING CLARITHROMYCIN POLYMORPHS AND NOVEL POLYMORPH IV
PROCESSES FOR PREPARING CLARITHROMYCIN POLYMORPHS AND NOVEL POLYMORPH IV
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机译:克拉霉素多聚体和新多聚体IV的制备方法
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摘要
The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.
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