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METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF
METHOD FOR DECREASING THE CONTACT BETWEEN HEPTA-REPEAT REGION S OF THE CORONA-VIRUS SPIKE PROTEINS AND USE THEREOF
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机译:减少冠状病毒斑突蛋白的七重复区域之间的接触的方法及其用途
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摘要
The invention relates to the field of coronaviruses and diagnosis, therapeutic use and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein comprising decreasing the contact between heptad repeat regions of said protein. The invention provides a peptide comprising a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an derivative thereof. The invention also provides antibodies and compounds inhibiting corona viral infection of cells, and/or cell-to-cell fusion. The invention also discloses heptad repeat regions and a fusion peptide of SARS-CoV.
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