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MYCOBACTERIUM TUBERCULOSIS INFECTION DIAGNOSTIC TEST
MYCOBACTERIUM TUBERCULOSIS INFECTION DIAGNOSTIC TEST
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机译:结核分枝杆菌感染诊断试验
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摘要
The invention provides a method of diagnosing Mycobacterium tuberculosis infection in a human, or of determining whether a human has been exposed to Mycobacterium tuberculosis, comprising: (i) contacting T-cells from said human with one or more of (a) a peptide having the sequence shown in SEQ ID NO: 1; (b) a peptide having or comprising the sequence of at least 8 consecutive amino acids of the sequence shown in SEQ ID NO: 1; or (c) a peptide having or comprising a sequence which is capable of binding to a T-cell receptor which recognises a peptide as defined in (a) or (b); and (ii) determining whether any of the said T-cells recognise said peptide, wherein steps (i) and (ii) are optionally carried out in vitro.
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机译:本发明提供了一种诊断人的结核分枝杆菌感染或确定人是否已暴露于结核分枝杆菌的方法,该方法包括:(i)使来自所述人的T细胞与一种或多种以下物质接触:(a)具有SEQ ID NO:1所示的序列; (b)具有或包含SEQ ID NO:1所示序列的至少8个连续氨基酸序列的肽; (c)具有或包含能够与识别(a)或(b)中定义的肽的T细胞受体结合的序列的肽;或(ii)确定任何所述T细胞是否识别所述肽,其中步骤(i)和(ii)任选地在体外进行。
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