USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS THEREOF FOR DIAGNOSIS AND PREVENTION OF MYCOBACTERIUM TUBERCULOSIS INFECTION, AND DIAGNOSTIC KIT AND VACCINE THEREFROM

摘要

PROBLEM TO BE SOLVED: To provide an in vitro test method for detection of Mycobacterium tuberculosis infection in a subject.SOLUTION: The present invention concerns the use of biomarkers being at least six peptides which are derived from Mycobacterium tuberculosis and comprise at least one T-cell epitope in association with ESAT6 and CFP10 and optionally with TB7.7. The peptides are selected from the group consisting of TAWITAVVPGLMV (SEQ ID NO:24), ELMARAAVLGSAH (SEQ ID NO:21), RPVRRVLLFVVPSSGPAP (SEQ ID NO:70), GSVRQLPSVLKPPLITLRTLTLSG (SEQ ID NO:71), GEIIFISGRLNGaa (SEQ ID NO:13), AVIVRSELLTQYL (SEQ ID NO:22), LAWITAVVPGLMV (SEQ ID NO:85), GEIIFISGRLNG (SEQ ID NO:86) and SALLRRLSTCPPES (SEQ ID NO:87).