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METHOD FOR ESTIMATING OR PREDICTING THE ANTI-TUMOR ACTIVITY OF A COMPOUND AND FOR ESTIMATING OR PREDICTING THE TUMOR GROWTH IN MAMMALS
METHOD FOR ESTIMATING OR PREDICTING THE ANTI-TUMOR ACTIVITY OF A COMPOUND AND FOR ESTIMATING OR PREDICTING THE TUMOR GROWTH IN MAMMALS
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机译:估计或预测化合物的抗肿瘤活性以及估计或预测哺乳动物肿瘤生长的方法
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摘要
The present invention relates to a method for estimating or predicting anti-tumor activity of a compound and for estimating or predicting the tumor growth in mammals; the estimation comprises a) measuring the tumor weight in time; b) measuring the concentration of the compound in time; c) calculating kinetic parameters of the tumor growth: -a parameter (LSUB0/SUB), representative of the portion of tumor cells present at the instant tSUB0/SUB=0 that succeeds in taking root and in starting tumor cells proliferation in the mammals; -an index (lambdaSUB0/SUB) of the production rate of tumor cells during an exponential phase of tumor growth; -an index (lambdaSUB1/SUB) of tumor cells mass produced in the time unit during a linear phase of the tumor growth; and pharmacodynamic parameters: -an index (KSUB1/SUB) of tumor cells death rate; -an index (KSUB2/SUB) of the potency of the compound; and d) calculating tumor growth curves.
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