INHIBITORS OF MELANIN BIOSYNTHESIS AND SCAVENGERS OF FREE RADICAL AND REACTIVE OXYGEN SPECIES FROM EUPENCILLIUM SHEARII F80695 AND NOVEL USE THEREOF

摘要

PURPOSE: Provided are inhibitors of melanin biosynthesis and scavengers of free radical and reactive oxygen species from Eupencillium shearii F80695 and the novel use thereof for scavenging reactive oxygen species and inhibiting lipid peroxides. CONSTITUTION: The melanosin A, B, C and D which are represented by the formulae(I), (II), (III), and (IV), respectively and isolated from Eupencillium shearii F80695 inhibit melanin biosynthesis, and scavenge reactive oxygen species.