COMPOSITION OF PACLITAXEL INJECTION HAVING IMPROVED CELL MEMBRANE PERMEABILITY AND EXCELLENT ANTICANCER EFFICACY

摘要

PURPOSE: Provided is a composition of paclitaxel injection which has high solubility of drugs and extended storage as well as improved cell membrane permeability and excellent anticancer efficacy. CONSTITUTION: The composition of paclitaxel injection having improved cell membrane permeability is characterized by comprising 0.0001-10 wt.% of paclitaxel, 30-49.999 wt.% of solubilizing agent selected from (oxyethylene)l sorbitol (olate)m or (oxyethylene)l sorbitan (olate)m, wherein l is an integer of 15-60 and m is an integer of 1-4, 0.0001-30 wt.% of cell membrane permeability-improving agent selected from conjugated linoleic acid phosphatidyl choline and docosahexaenoic acid phosphatidyl choline, and 30-49.999 wt.% of anhydrous alcohol selected from anhydrous ethanol, anhydrous isopropylalcohol, anhydrous-n-propylalcohol and t-butylalcohol.