MUTANT BASIC FIBROBLAST GROWTH FACTOR HAVING INCREASED SECRETION EFFICIENCY

摘要

The present invention relates to a transformed cell transduced with a recombinant vector and the recombinant vector containing the gene, the gene secretion efficiency is increased by encoding a mutant bFGF protein, said protein and, more specifically, SEQ ID NO: 6 relates to a transfected with mutant bFGF proteins, animal cells expressing recombinant vector and the recombinant vector for the gene encoding the bFGF mutant proteins, containing the gene to be introduced into base material transformed cells. Mutant bFGF proteins of the invention may usefully be used to mass-produce the bFGF protein that since the secretion efficiency superior extracellular be used for ischemic cardiovascular diseases due to trauma, angiogenesis, atherosclerosis, or restenosis.