DNA CHIP FOR SCREENING INHIBITOR OF GAP JUNCTION INTERCELLULAR COMMUNICATION

摘要

The present invention provides a DNA chip comprising a gene probe capable of specifically binding to a gene expressed upon administration of an intercellular signal transduction inhibitor through a gap binding, a method for producing an electrical DNA chip, and a gap binding including an electrical DNA chip. The present invention relates to a method for selecting intracellular signaling inhibitors through intracellular signal transduction inhibitors using kits and electric kits. DNA chip for intercellular signaling inhibitor selection through gap binding of the present invention is composed of 216 to 477 nucleotides, genes that can specifically bind to the gene expressed by the intracellular signaling inhibitors through gap binding probe; A linker comprising oligo (dT) ₁₅ ,-(CH ₂ ) ₆ -and an amine group sequentially, wherein the 5 ′ end of the electric gene probe is connected to the 3 ′ end of oligo (dT) ₁₅ ; And a solid substrate to which an aldehyde is attached to the surface, and an amine group of the electric linker is connected through a reaction of the aldehyde group on the surface with a Schiff's base. The intercellular signal transduction inhibitor selection kit of the present invention can be widely used for the safety testing of various materials, since the kit for screening an intercellular signal transduction inhibitor may be selected in advance for damaging or genetically modifying a cell. .