Remedies/Preventives for frequent urination/Urinary incontinence and Tropone derivatives

摘要

Remedies / preventives (therapeutic or preventive agents) against frequent urination (pollakiuria) / urinary incontinence which contain as an active ingredient compound having a tropone structure or pharmacologically acceptable salt thereof and a novel compound having the tropone structure. The compounds having a tropone structure and having the above pharmacological effects are those represented by, for example, general (1): CHEM wherein R1 and R2 represent each a hydrogen atom, lower alkyl group, etc., R3 represents -OR or -NR2 ; R4, R5 and R12 represents each a hydrogen atom or a lower alkyl group, X represents a nitrogen atom or CH, Z represents -CHAr2, an unsubstituted or substituted phenyl, etc. m is 1 or 2. These compounds are novel ones excluding those wherein Z is -CH Ar2.