METHOD FOR OBTAINING OLANZAPINE HYDRATES AND TRANSFORMING THEM IN CRYSTAL FORMS OF OLANZAPINE

摘要

The present invention relates to a method for the preparation of hydrates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b] [1,5] benzodiazepine (hereinafter referred to as Olanzapine). The present invention also relates to a process for conversion of these hydrates into a pure crystalline form of olanzapine referred to as form-I. The present invention also relates to a method of converting Olanzapine Form-2 to Form-1.