The lyophilized material with vaccinia viral activity of 4.5 - 6.0 ffu per lg 1,04-31,3; ; tablet; <TableGroup colSep="0" cols="2" rowSep="0"> <Colspec colName="c0"/> <Colspec colName="c1"/> <Tbody> <Row> <entry align="left"> Peptone</entry> <entry align="right"> 0,12-3,8;</entry> </Row> <Row> <entry align="left"> Zhelatoza</entry> <entry align="right"> 0,06-1,9;</entry> </Row> <Row> <entry align="left"> saccharose</entry> <entry align="right"> 10,1-11,55;</entry> </Row> <Row> <entry align="left"> buffer</entry> <entry align="right"> 0,001-0,027;</entry> </Row> <Row> <entry align="left"> calcium stearate</entry> <entry align="right"> 1,94-2,0;</entry> </Row> <Row> <entry align="left"> Vanillin</entry> <entry align="right"> 0,17-0,2;</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> ; Lactose balance to 100%. Acid-shell tablet before its four-fold by covering the surface of the nucleus comprises shellac, oleic acid, ammonia water 25% solution and distilled water at the following contents of components in parts by weight: shellac - 10.0; acid oleinovaya- 2.0; aqueous ammonia 25% -3.0; distilled water - 85.0."/> <meta property="og:document:type" content="pdf"/> <meta property="og:document:page" content="9999"/> <meta name="Robots" contect="all"> <link rel="canonical" href="https://www.zhangqiaokeyan.com/patent-detail/06130439120619.html"/> <link rel="shortcut icon" href="https://cdn.zhangqiaokeyan.com/favicon.ico"> <link rel="alternate" media="only screen and (max-width: 640px)" href="https://m.zhangqiaokeyan.com/patent-detail/06130439120619.html"/> <title>Tableted LIVE recombinant bivaccine 'REVAKS CGT' against smallpox and hepatitis B to enteral administration

首页> 外国专利> Tableted LIVE recombinant bivaccine 'REVAKS CGT' against smallpox and hepatitis B to enteral administration

Tableted LIVE recombinant bivaccine 'REVAKS CGT' against smallpox and hepatitis B to enteral administration

机译：片剂抗天花和乙型肝炎的LIVE重组重组牛痘疫苗“ REVAKS CGT”用于肠内给药

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The invention relates to medicine, in particular, to the immunology and can be used for specific prevention of infectious viral hepatitis and smallpox. The vaccine in the form of tablets with acid-resistant shell is at a low immunizing dose forming protective level of specific immunity. Bivaccine based on vaccinia virus for oral administration comprising per tablet the lyophilized viral material accumulated based on recombinant vaccinia virus strain STB №2131 with typical properties of vaccinia virus expressing preS 2-Ag HbsAg and HCV activity in a 4.5-6, 0 lg pfu per tablet, lactose, sucrose, calcium stearate, and vanillin, peptone, and zhelatozu buffer. Recombinant vaccinia virus has gained in continuous culture of animal cells in the following ratio of components per nucleus tablet (wt.%):;

<TableGroup colSep="0" cols="2" rowSep="0"> <Colspec colName="c0"/> <Colspec colName="c1"/> <Tbody> <Row> <entry align="left"> The lyophilized material with vaccinia viral activity of 4.5 - 6.0 ffu per lg</entry> <entry align="right"> 1,04-31,3;</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> ; tablet; <Table> <TableFormula> <Title/> <TableGroup colSep="0" cols="2" rowSep="0"> <Colspec colName="c0"/> <Colspec colName="c1"/> <Tbody> <Row> <entry align="left"> Peptone</entry> <entry align="right"> 0,12-3,8;</entry> </Row> <Row> <entry align="left"> Zhelatoza</entry> <entry align="right"> 0,06-1,9;</entry> </Row> <Row> <entry align="left"> saccharose</entry> <entry align="right"> 10,1-11,55;</entry> </Row> <Row> <entry align="left"> buffer</entry> <entry align="right"> 0,001-0,027;</entry> </Row> <Row> <entry align="left"> calcium stearate</entry> <entry align="right"> 1,94-2,0;</entry> </Row> <Row> <entry align="left"> Vanillin</entry> <entry align="right"> 0,17-0,2;</entry> </Row> </Tbody> </TableGroup> </TableFormula> </Table> ; Lactose balance to 100%. Acid-shell tablet before its four-fold by covering the surface of the nucleus comprises shellac, oleic acid, ammonia water 25% solution and distilled water at the following contents of components in parts by weight: shellac - 10.0; acid oleinovaya- 2.0; aqueous ammonia 25% -3.0; distilled water - 85.0. </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span>本发明涉及医学，尤其涉及免疫学，可用于特异性预防传染性病毒性肝炎和天花。具有抗酸外壳的片剂形式的疫苗以低免疫剂量形成特异性免疫的保护水平。基于牛痘病毒的口服口服比伐他汀，每片包含基于重组牛痘病毒STB№2131积累的冻干病毒材料，该疫苗具有典型的牛痘病毒特性，可在4.5-6，0 lg pfu中表达preS 2-Ag HbsAg和HCV活性片剂，乳糖，蔗糖，硬脂酸钙，香兰素，蛋白ept和zhelatozu缓冲液。重组痘苗病毒在动物细胞的连续培养中获得了以下组成的比例，每核片剂的成分比例（重量％）： <表格> <TableFormula> <标题/> <TableGroup colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec colName =“ c0” /> <Colspec colName =“ c1” /> <身体> <行> <entry align =“ left”>牛痘病毒活性为每升4.5-6.0 ffu的冻干物质</ entry> <entry align =“ right”> 1,04-31,3; </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> ;片剂; <表格> <TableFormula> <标题/> <TableGroup colSep =“ 0” cols =“ 2” rowSep =“ 0”> <Colspec colName =“ c0” /> <Colspec colName =“ c1” /> <身体> <行> <entry align =“ left”>蛋白ept </ entry> <entry align =“ right”> 0,12-3,8; </ entry> </ Row> <行> <entry align =“ left”> Zhelatoza </ entry> <entry align =“ right”> 0,06-1,9; </ entry> </ Row> <行> <entry align =“ left”>蔗糖</ entry> <entry align =“ right”> 10,1-11,55; </ entry> </ Row> <行> <entry align =“ left”>缓冲区</ entry> <entry align =“ right”> 0,001-0,027; </ entry> </ Row> <行> <entry align =“ left”>硬脂酸钙</ entry> <entry align =“ right”> 1,94-2,0; </ entry> </ Row> <行> <entry align =“ left”>香兰素</ entry> <entry align =“ right”> 0,17-0,2; </ entry> </ Row> </ Tbody> </ TableGroup> </ TableFormula> </ Table> ;乳糖平衡至100％。通过覆盖核表面四倍的酸壳片剂包含虫胶，油酸，25％的氨水溶液和蒸馏水，其中以下组分的重量份含量为：虫胶-10.0;酸oleinovaya- 2.0;氨水25％-3.0;蒸馏水-85.0。 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33">著录项</h2> <div class="getdents"> <ul> <li> <p><span>公开/公告号</span><span>RU47743U1</span></p> <p><span>专利类型</span><span></span></p> </li> <li> <p><span>公开/公告日</span><span>2005-09-10</span></p> <p><span>原文格式</span><span>PDF</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">申请/专利权人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请/专利号</span><span style="width: 250px;">RU20040130657U</span></p> </li> <li> <div class="apply"> <p><span style="width: 90px;display: inline-block;">发明设计人</span><span id="patentee" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=12_13&sertext=СЕРГЕЕВ А.А. 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(RU);</a> </span></p> <span class="designer hoverxs" style="display: none;">展开▼</span> </div> <p><span>申请日</span><span>2004-10-21</span></p> </li> <li> <p style="width: 100%;"><span>分类号</span><span style="width: 80%;">A61K9/20;A61K39/12;</span> </p> </li> <li> <p style="width: 100%;"><span>国家 </span><span style="width: 93%;">RU</span></p> </li> <li><p style="width: 100%;"> <span >入库时间</span> <span>2022-08-21 22:01:47</span></p> </li> </ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity"> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul > <li >专利</li> <li >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112651227.html">重组乙型肝炎抗原冻干保护剂、重组乙型肝炎抗原冻干疫苗及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN112675134A </span> <span> . 2021-04-20</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" 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