A method for measuring the laboratory activity and a method for screening inhibitors or promoters of this enzyme

摘要

The acetylation level of a peptide is evaluated by taking advantage of the fact that a change in the acetylation level affects the peptidase sensitivity of a substrate peptide. This method is usable in measuring the activity of a deacetylase or an acetylase. It is also possible to screen a substance affecting the activity of these enzymes thereby. Thus, the activity of a deacetylase can be conveniently measured.