首页>
外国专利>
transkriptioneller korepressor which with hormone receptors of the nucleus wechselwirkt and its applications
transkriptioneller korepressor which with hormone receptors of the nucleus wechselwirkt and its applications
展开▼
机译:韦氏核素的激素受体的transkriptioneller korepressor及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
In accordance with the present invention, there are provided novel receptor interacting factors, referred to herein as "SMRT", i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR and TR both in solution and on DNA response elements is destabilized by ligand. The interaction of SMRT with mutant receptors correlates with the transcriptional silencing activities of receptors. In vivo, SMRT functions as a potent co-repressor. A GAL4 DNA binding domain (DBD) fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, these data identify a novel class of cofactor which is believed to represent an important mediator of hormone action.
展开▼