PYRAZOLOPYRIDINE DERIVATIVE AS SELECTIVE COX-2 INHIBITORS

摘要

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: RSUP0 /SUPand RSUP1 /SUPare independently selected from the group consisting of H, halogen, CSUB1-6/SUBalkyl, CSUB1-6/SUBalkoxy, and CSUB1-6/SUBalkoxy substituted by one or more fluorine atoms; RSUP2 /SUPis selected from the group consisting of H, CSUB1-6/SUBalkyl, CSUB1-6/SUBalkyl substituted by one or more fluorine atoms, CSUB1-6/SUBalkoxy, CSUB1-6/SUBhydroxyalkyl, SCSUB1-6/SUBalkyl, C(O)H, C(O)CSUB1-6/SUBalkyl, CSUB1-6/SUBalkylsulphonyl, and CSUB1-6/SUBalkoxy substituted by one or more fluorine atoms; and RSUP3 /SUPis CSUB1-6/SUBalkyl or NHSUB2/SUB. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.