Pyrazolopyridine derivatives as selective cox-2 inhibitors

摘要

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein:R⁰ and R¹ are independently selected from the group consisting of H, halogen, C_1-6alkyl, C_1-6alkoxy, and C_1-6alkoxy substituted by one or more fluorine atoms;R² is selected from the group consisting of H, C_1-6alkyl, C_1-6alkyl substituted by one or more fluorine atoms, C_1-6alkoxy, C_1-6hydroxyalkyl, SC_1-6alkyl, C(O)H, C(O)C_1-6alkyl, C_1-6alkylsulphonyl, and C_1-6alkoxy substituted by one or more fluorine atoms; andR³ is C_1-6alkyl or NH₂.;Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.