AGENT FOR INHIBITING METASTASIS AND INFILTRATION OF CANCER CELL BY INHIBITION OF EXPRESSION OF CRK ADAPTOR MOLECULE

摘要

PPROBLEM TO BE SOLVED: To provide a cancer remedy for preventing the infiltration and metastasis of cancer. PSOLUTION: This agent for preventing the infiltration and metastasis of human cancer contains as an active ingredient a recombinant retrovirus which expresses a c-Crk double-stranded siRNA (small interference RNA) containing a nucleotide chain selected from the group consisting of GCCUGAAGAGCAGUGGUGG(sequence No. 1), AAGCCUGAAGAGCAGUGGUGG(sequence No. 2), GCCUGAAGAGCAGUGGUGGAAG(sequence No. 3) and AAGCCUGAAGAGCAGUGGUGGAAG(sequence No. 4) and a nucleotide chain complementary thereto. PCOPYRIGHT: (C)2006,JPO&NCIPI