Hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

摘要

A compound having the following formula (I): wherein RSUP1 /SUPis N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), RSUP2 /SUPis hydroxyamino, RSUP3 /SUPis hydrogen or a suitable substituent, LSUP1 /SUPis -(CHSUB2/SUB)SUBn/SUB- (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and LSUP2 /SUPis lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.