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NEW SUBSTITUTED HYDROXAMIC ACID DERIVATIVE WITH HDAC (HISTONE DEACETYLASE) INHIBITING ACTIVITY
NEW SUBSTITUTED HYDROXAMIC ACID DERIVATIVE WITH HDAC (HISTONE DEACETYLASE) INHIBITING ACTIVITY
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机译:具有HDAC(组氨酸硬脂酸)抑制活性的新的取代羟基乙酸衍生物
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摘要
PROBLEM TO BE SOLVED: To provide a new carcinostatic and therapeutic agent for immunological disease having HDAC (Histone Deacetylase) inhibiting activity.;SOLUTION: The invention relates to the substituted hydroxamic acid derivative represented by general formula (1) and its pharmaceutically permissible salt and its hydrate [in the formula, A is a nitrogen or carbon atom, B and D are each the same or different carbonyl group or methylene group, E is a CH=CH group, a CH2-CH2 group or O-CH2 group, F is a (substituted)phenyl group, a phenethyl group, a 3-phenylpropyl group, a cyclohexyl group, a naphthyl group, etc.].;COPYRIGHT: (C)2007,JPO&INPIT
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