Sorubicil lactone A and sorbicil lactone A derivatives, methods for producing them, agents containing them, and uses thereof

摘要

Benzofuranone derivatives (I), i.e. the natural product sorbicillactone A and its derivatives, are new. Benzofuranone derivatives of formula (I) and their salts or solvates are new. R1 = H, 1-10C alkyl, 3-10C alkyl, acyl (e.g. CHO, COMe, COCCl3, fumaryl or succinyl, in which any free COOH groups are optionally in ester form, e.g. as the methyl ester), 5-methoxycarbonyl-4,5-dihydro-1H-pyrazol-4-yl or 4-methoxycarbonyl-4,5-dihydro-1H-pyrazol-5-yl; R2, R3 = H, 1-10C alkyl or acyl (e.g. CHO or COMe); R4 = 1-10C alkyl or 3-10C alkenyl (optionally containing more than one double bond); X = O, S, NOH or NOR5; Y = O; or X and Y = two N-atoms bonded to complete a pyrazole ring; and R5 = 1-6C alky. (I) can be in the form of the (R,R,R), (R,R,S), (R,S,R), R,S,S), (S,R,R), (S,R,S), (S,S,R) or (S,S,S)-stereomer. Independent claims are included for the preparation of (I).