Early of disease the system for detecting, and the disease uniqueness development of the bio marker

摘要

As for this invention, being method for detecting the disease of the specification in the mammal, thing and the aforementioned NMR spectrum which prepare the NMR spectrum of the metabolite in the body fluids of the individual of the aforementioned mammal where the aforementioned disease is doubted it includes the fact that it compares with the difference profile which includes plural NMR spectrum line positions, those correspond the NMR spectrum of 1 or more of the metabolite in the body fluids of the healthy individual of 1 or more of the aforementioned mammal and, 1 or more of the metabolite in the body fluids to which the individual of 1 or more of the aforementioned mammal where the aforementioned disease is diagnosed correspondsIt regards the method of the place where the difference where with of the NMR spectrum is formalized is shown. In addition as for this invention, it regards the aforementioned difference profile for detecting the disease in the aforementioned mammal, and the method for that compilation. In addition as for this invention, disease of specification, the bio marker for detecting the especially deformation characteristic arthropathy, and that bio marker in detecting the deformation characteristic arthropathy it regards the use.