Plasminogen fragment having tumor metastasis growth inhibitory effect and method for preparing the fragment

摘要

Fragments of a plasminogen effective in inhibiting tumor metastasis and growth, a process for preparing the fragments, and a tumor metastasis and growth inhibitor containing the fragments as the active ingredient. The fragments are obtained from the elastase-induced hydrolysis product of Lys-plasminogen obtained by treating a plasminogen with plasmin and preferably have a potent heparin-binding activity. The inhibitor is useful for clinical therapy of solid cancers typified by lung and colon cancers.