Novel proteins involved in nuclear translocation of substances in neurons, genes encoding the proteins, and uses thereof

摘要

The novel protein CRAG isolated and identified by the present inventor as a CRAM binding protein consists of the amino acid sequence shown in SEQ ID NO: 2, and has a GTPase active sequence and a nuclear translocation signal sequence. As a result of functional analysis, this protein CRAG is involved in nuclear translocation of substances in nerve cells, and is also involved in nuclear translocation of denatured protein and elimination of the denatured protein in polyglutamine disease. It was. As described above, the present invention provides a novel protein involved in the nuclear translocation of a substance in a nerve cell, a gene encoding the protein, and the like. Therefore, the present invention can be expected to be used for diagnosis and treatment of such neurodegenerative diseases.