Live bacterial preparation of bacillus coagulans for the treatment of ulcerative colitis, method for producing the same and use thereof

摘要

The present invention discloses a method for preparation of live Bacillus coagulans and the use of the bacteria in treatment of ulcerative colitis. The live bacteria are effective in the treatment of experimental ulcerative colitis in rats. They are also used in the clinical treatment of patients suffering from ulcerative colitis and the efficacy and safety are evaluated. The present invention also discloses the formulation and production method of the live bacterial preparation of Bacillus coagulans, the count of live bacterial in the preparation, and dosage form of the preparation. The present invention shows that the live bacterial preparation is effective and safe for treatment of ulcerative colitis, and the stability of said preparation is good and could be stored at room temperature. Patients can take the preparation for a long term without adverse effect. The present invention provides a new means for the treatment of ulcerative colitis and a new use of live bacterial preparation of Bacillus coagulans in treating ulcerative colitis.