A new chronic ulcerative colitis model produced by combined methods in rats

摘要

INTRODUCTIONThe etiopathogenesis of ulcerative colitis (UC)remains obscure,due to lack of an ideal animalmodel.With thc improvement of theory andmethodology in the last 30 years,people used toadopt chemicals(acetic acid,ethanol,carrageen,etc.),immunotechniques(humoral or cellularimmunity,immune complex) and substance derivedfrom UC patients to set up various kinds of UCanimal model,which mimic the pathologic changesof human UC,so far these remain far