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Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
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机译:骨髓来源的神经胶质祖细胞作为基因传递载体进入中枢神经系统的用途
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摘要
The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.
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