New derivatives of echinocandine, their preparation process and their use as antifungals

摘要

A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I): in which either R₁: H or CH₃ and R₂: cyclohexyl substituted by an amine, a (CH₂)b—C≡N radical or R₁ and R₂ together with the nitrogen which carries-them form a ring with 3, 4 or 5 carbons optionally substituted by an amine R₃: hydrogen, methyl or hydroxyl R₄: hydrogen or hydroxyl R: represents a linear,. branched or cyclic chain T: hydrogen, methyl, CH₂CONH₂, CH₂C≡N, a (CH₂)₂NH₂ or (CH₂)₂Nalk⁺X⁻ radical, X halogen and alk alkyl Y: hydrogen, hydroxyl, halogen or OSO₃H, W: H or OH, Z: H, CH₃. The compounds of formula (I) have antifungal properties.