Derivatives of echinocandine, their preparation process and their use as antifungals

摘要

A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I):; in whicheither R₁: H or CH₃ andR₂: cyclohexyl substituted by an amine, a (CH₂)b-C≡N radical or R₁ and R₂ together with the nitrogen which carries them form a ring with 3, 4 or 5 carbons optionally substituted by an amineR₃: hydrogen, methyl or hydroxylR₄: hydrogen or hydroxylR: represents a linear, branched or cyclic chainT: hydrogen, methyl, CH₂CONH₂, CH₂C≡N, a (CH₂)₂NH₂ or (CH₂)₂Nalk⁺X⁻ radical, X halogen and alk alkylY: hydrogen, hydroxyl, halogen or OSO₃H,W: H or OH,Z: H, CH₃.;The compounds of formula (I) have antifungal properties.