SNPs in 5' regulatory region of MDR1 gene

摘要

The present invention relates to a method for determining haplotypes or diplotypes of a MDR1 gene targeting the 5′ upstream regulatory region of MDR1 gene encoding P-gp, an ABC transporter which is may be expressed in the apical membrane side and may transport a wide range of substrates. By detecting a polymorphism at −934 and/or −692, in addition to a position selected from −2903, −2410, −2352, −1910, −1717, and −1325 in a nucleotide sequence of the 5′ upstream regulatory region of MDR1 gene, haplotypes or diplotypes of the 5′upstream regulatory region of MDR1 gene may be determinable. The above positions to detect polymorphism are indicated in relation to a first base of ATG start codon which is set to +1. ATG start codon is located in exon 2, and the transcription start site corresponds to −699 in this numbering system.