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Antagonism of TGF-beta superfamily receptor signaling
Antagonism of TGF-beta superfamily receptor signaling
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机译:TGF-β超家族受体信号传导的拮抗作用
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摘要
Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-β superfamily members, in particular activin-A antagonist.
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