Antagonism of TGF-BETA Superfamily Receptor Signaling.

摘要

Members of the TGF-beta superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-beta ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-beta superfamily members, in particular activin-A antagonist.