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Novel recombinant sabin type 1 poliovirus vector and vaccine against poliovirus
Novel recombinant sabin type 1 poliovirus vector and vaccine against poliovirus
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机译:新型重组沙宾1型脊髓灰质炎病毒载体和抗脊髓灰质炎病毒的疫苗
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摘要
The present invention relates to a novel recombinant Sabin type 1 poliovirus vector for the immunogenicity of neutralizing antibody against polioviral infection, which comprises: (a) a genomic nucleotide sequence of a parent Sabin type 1 poliovirus; (b) a nucleotide sequence encoding an additional polioviral cleavage site; and (c) a nucleotide sequence of a conformational epitope encoding a VP1 neutralizing epitope of poliovirus type 2 or 3 and linked to the nucleotide sequence of (b).
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