Diagnosis and treatment of fanconi's anemia

摘要

The novel FLJ11011 gene encoding a human ubiquitin-conjugating (E2) enzyme as well as gene fragments, coding sequences, mRNA variants and encoded proteins are disclosed. Additionally, methods of diagnosing and treating a patient that has or is suspected of having Fanconi's anemia or increased susceptibility to cancer or diminished capability of DNA repair. Additionally, methods of identifying compounds with the potential to treat or ameliorate Fanconi's Anemia are provided.