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Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
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机译:诸如磷脂酶和透明质酸酶之类的蛇毒毒酶的克隆和重组生产,以及以此为基础的免疫疗法
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摘要
A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent “intronic” sequences. In still a further enbodiment, genetic engineering permits the construction of the “intronic” sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.
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