Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries

摘要

Workstation, apparatuses and methods for the high-throughput synthesis, screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high-throughput methods for synthesis, screening and/or characterization in the same array, without requiring sample transfer from the array. In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. The invention may be practiced at the microscale. The array may comprise thermal channels, for regulating the temperature of the wells in the array. The wells of the array may comprise a membrane, which is used in various screening and characterization methods. The invention also relates to a covered array, comprising the array and an array cover, as well as an apparatus comprising the array, which comprises the array, an array cover and a stage. The array, array cover, and the stage may be modified as required for a variety of synthesis and/or analysis techniques. The array is easily interchangeable between different analytical instruments, and in an embodiment, the invention relates to an automated workstation, where the array is transferred between different synthesis, screening, and characterization stations. The invention also relates to a variety of methods for synthesis, screening, and characterization, which are adapted for combinatorial chemistry. Any of the embodiments of the invention may be used either alone or taken in various combinations.