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Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
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机译:非酶催化信号扩增,用于核酸杂交测定
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摘要
Devices, methods, and kits for amplifying the signal from hybridization reactions between nucleic acid probes and their cognate targets are presented. The devices provide partially-duplexed, immobilized probe complexes, spatially separate from and separately addressable from immobilized docking strands. Cognate target acts catalytically to transfer probe from the site of probe complex immobilization to the site of immobilized docking strand, generating a detectable signal. The methods and kits of the present invention may be used to identify the presence of cognate target in a fluid sample.
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