Indazol indolona derivatives as agonists and Selective Dopamine D3; Pharmaceutical compositions containing them and their use in the preparation of drugs for the treatment of sexual Dysfunctions

摘要

This product provides formula compound (1),They are a stimulant of dopamine, especially a stimulant, and they choose D3 over D2. These compounds are useful in the treatment and / or prevention of sexual dysfunction, for example, female sexual dysfunction (DSF),Especially in women with sexual arousal disorder (tesf)Low activity of sexual desire disorder (tdsh, lack of interest in sex)Female orgasmic disorder (TOF) and male sexual dysfunction, especially male erectile dysfunction (DEM). The male sexual dysfunction referred to in this report is intended to include sexual desire disorders such as early ejaculation, anaerosis (inability to reach orgasm), or low activity sexual desire disorders. ILO Convention No. 1: formula compounds (1)In the case where a is selected from n or C = O, X is selected from h, methyl, ethyl, oh, OCH3, och2ch3, halo, SC3, CN or CF3, the punctuation line (formula point link (1)) represents a simple link when a is n, but does not exist when a is C = O; R1 is selected from formula (2),(3) And (4),Z stands for or CH2; R2 stands for H or C1-6 aspha C1-6 asphalt may be replaced by C1-6, or8, phenyl or heterogeneous aspha R3 stands for H or C1-6 aspha C1-6 asphalt may be replaced; R4 stands for H or C1-6 aspha R5 stands for H, methyl, ethyl, thyroid or etoxi; R6 stands for C1-6 tar; R7 stands for H or C1-6 tar; C1-6 tar can be selectively replaced by one or two alternatives selected from or8, phenyl or phenyl alternatives; R8 stands for H, C1-6 tar, phenyl or (CH2) phenyl;Heteromorphism refers to an aromatic ring with 5 to 7 members, consisting of 1 to 4 heteroatoms, each of which can be selected independently; heteromorphism refers to one or more substitutes selected from C1-6 tar, halogen and or8, Alternatives may be the same or different; in alternatives, phenyl refers to the substitution of phenyl with one or more alternatives selected from C1-6 tar, halogen and or, each of which is the same or different; and salt, solution, polymorphine and pharmaceutical derivative acceptable under the condition of Z. Or, when a is C, or a is C, orX is h, R1 is formula (4),So R5 can't be H