pharmaceutical composition comprising a bispecific antibody construct for epcam, process for its production, use of a bispecific construct, kit containing same and method for the prevention, treatment or alleviation of a tumor disease

摘要

"PHARMACEUTICAL COMPOSITION UNDERSTANDING A SPECIFIC BIO-SPECIFIC CONSTRUCTION FOR EPCAM, PROCESS FOR THEIR PRODUCTION, USE OF A BIO-SPECIFIC CONSTRUCTION, KIT CONTAINING THE SAME AND METHOD FOR PREVENTION, TREATMENT OR ALIUM." The present invention provides a pharmaceutical composition comprising a single chain bispecific antibody construct. Said single chain bispecific antibody construct is characterized in that it comprises or consists of at least two domains, wherein one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the sequence antigen. amino acids NXD and a second domain that binds to the human CD3 antigen. The invention further provides a process for producing the pharmaceutical composition of the invention, a method for the prevention, treatment or alleviation of a tumor disease and the use of the disclosed single chain bispecific antibody construct and corresponding means for the prevention, treatment or alleviation of a tumor disease.