compound, pharmaceutical composition, and methods for treating or preventing cancer in a mammal in need of such treatment, for modulating mitotic spindle formation and for inhibiting mitotic kinesin ksp

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, AND METHODS FOR TREATING OR PREVENTING CANCER IN A MAMMER IN NEED OF SUCH TREATMENT, FOR MODULATING THE FORMATION OF THE MYTHOSTIC KINESIN". The present invention relates to dihydropyrrol compounds of formula (I) which are useful for treating cell proliferative diseases, for treating disorders associated with KSP kinesin activity and for inhibiting KSP kinesin. The invention also relates to compositions comprising these compounds, and methods of their use to treat mammalian cancer.