composition for the prevention / treatment of hbv infections and hbv mediated diseases and method for preparing a medicament for the therapeutic treatment of hepatitis b

摘要

"COMPOSITION FOR THE PREVENTION / TREATMENT OF HBV INFECTIONS AND HBV MEDIATED DISEASES AND METHOD FOR PREPARING A MEDICINAL PRODUCT FOR HEPATITIS B THERAPEUTIC TREATMENT". The present invention relates to compositions comprising at least two hepatitis B virus surface antigens (HBsAg 39 s), fragments and / or nucleic acids encoding said antigens, HBsAg 39 s in the genotype of Hepatitis B virus. hepatitis B (HBV) differing in the S and / or pre-S1 region and the composition being free of HBV core antigen (HBcAg) or nucleic acids encoding said antigen. The invention also relates to pharmaceutical compositions, especially vaccines comprising said compositions for the prevention / treatment of HBV infection or HBV mediated disease. The invention further relates to a method for producing a patient-specific medicament for the therapeutic treatment of hepatitis B.