Chimeric infectious DNA clone, Chimeric porcine circovirus and Use thereof

摘要

1. - a Nucleic Acid Molecule infectious Chimeric porcine circovirus (PCV1 - 2) wherein a Nucleic Acid Molecule that encodes a non infectious pathogenic PCV1 Gene contains an open reading frame (ORF) of a pathogenic PCV2 immunogenic in place A Gene of ORF of the Nucleic Acid Molecule of pcv1.13.- a viral vaccine that protects against viral infection or a Pig multisystemic wasting syndrome (PMWS) post weaning caused by PCV2Characterized in that it comprises a non-toxic pharmaceutically acceptable vehicle and an immunogenic amount a member selected from the group consisting of: (a) a Chimeric Nucleic Acid Molecule which has a Nucleotide sequence in SEQ ID no: 2Its complementary Strand or a sequence of nucleotides that have at least 95% Homology in the Nucleotide sequence of SEQ ID no: 2; (b) a Biologically Functional Plasmid or viral vector containing the Chimeric Nucleic Acid Molecule.The complementary chain or sequence of nucleotides that have at least 95% Homology in the Nucleotide sequence of SEQ ID no: 2; (c) a Chimeric porcine circovirus diseaseAvirulent; (d) a polypeptide which has an Amino Acid Sequence SEQ ID no: 4 exposed in Biologically Active or a Variant thereof; (e) an infectious molecular clone of PCV2 DNA that has Deposit designation Patent ATCC PTA bags-3913 or a clone of PCV2 DNA derived therefrom; and (f) a Biologically Functional Plasmid or viral vector containing the DNA molecular clone of PCV2 inFeccioso Deposit designation that has Patent ATCC PTA bags-3913 clone of PCV2 DNA or a derivative thereof.