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CC-CHEMOKINE MUTANTS AS CC-CHEMOKINE ANTAGONISTS
CC-CHEMOKINE MUTANTS AS CC-CHEMOKINE ANTAGONISTS
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机译:CC-CHEMOKINE突变体作为CC-CHEMOKINE拮抗剂
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摘要
Mutants of specific CC-chemokines containing a non-conservative substitution in a conserved consensus sequence act as CC-chemokine antagonists, and can be effectively used in the treatment of autoimmune and inflammatory diseases, cancers, and viral or bacterial infections. Particularly preferred are the RANTES/CCL5 mutants having the amino acid sequence of SEQ ID NO: 1, 2 , 3, or 4.
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机译:在保守的共有序列中包含非保守取代的特定CC趋化因子的突变体充当CC趋化因子拮抗剂,可有效用于自身免疫和炎性疾病,癌症以及病毒或细菌感染的治疗。特别优选的是具有SEQ ID NO:1、2、3或4的氨基酸序列的RANTES / CCL5突变体。
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